Fecal immunological test results and diagnostic colonoscopy in a Mexican population at average risk for colorectal cancer

Colorectal cancer (CRC) is a preventable and treatable with screening and early detection. Fecal immunochemical test (FIT) for average risk individuals is an effective strategy for screening. The incidence and mortality in Mexico has increased and large-scale screening program does not exist. The objective is to evaluate the feasibility of the FIT-based CRC screening program in Mexico City. For 15 months, the average risk individuals in Mexico City were invited to participate in the Mexican National Cancer Institute (Inca).

Participants receive FIT kit for collection of stool, the result ≥20ng / mL was referred to the high quality colonoscopy. Participants were classified according to the results of the most advanced clinical findings as: adenocarcinoma, adenoma, high risk, low risk adenomas, serrated lesions, hyperplastic polyps and no polyps. sequential analysis was performed to assess the positive predictive value (PPV) of the FIT. Eight hundred and ten participants were eligible, 737 (91.0%) returns FIT and 112 (15.2%) had abnormal results. Of the participants, 87 (77.7%) completed colonoscopy.

Clinical findings from participants included: 7 (8.1%) adenocarcinomas, 18 (20.7%) high-risk adenomas, 23 (26.4%) low-risk adenoma, 1 (1.2%) serrated lesions, 14 ( 16.1%) hyperplasic polyps, and 24 (27.6%) no polyps. PPV of FIT using the ≥20ng / mL was 8.1% for cancer and 20.7% for high-risk adenomas. In conclusion CRC screening with FIT worth Inka in Mexico City, where the available resources. Further studies are needed to determine the feasibility of CRC screening in other settings, as well as the optimal detection points hemoglobin cutoff to maximize the benefits of CRC screening with FIT population in Mexico.


the rapid spread of the coronavirus disease in 2019 (COVID-19) swept the world. Since the first report in December 2019 COVID-19 case has exploded to over 14 million in July 2020, claiming more than 600,000 lives. Applying a quick and comprehensive diagnostic test is essential to contain COVID-19, given the current lack of an effective vaccine or therapeutic. This review focuses on a comprehensive description of current diagnostic tests are available to detect both immune response virus (SARS-CoV-2) or virus-induced. We specifically explain the mechanism of action of this test and compare the performance of their analysis.

This analysis will help in selecting the most effective test for certain applications, for example, epidemiology, or the study of global pandemics, population screening, hospital-based testing, home-based testing and point-of-care, and therapeutic trials. Finally, we lay out the shortcomings of certain tests and future needs.

 Fecal immunological test results and diagnostic colonoscopy in a Mexican population at average risk for colorectal cancer
Fecal immunological test results and diagnostic colonoscopy in a Mexican population at average risk for colorectal cancer

Clinical and immunological profile of Disease Mixed Connective Network and Comparison of Four Diagnostic Criteria.

mixed connective tissue disease (MCTD) was originally described as an immune-mediated chronic diseases with overlapping features of systemic lupus erythematosus, scleroderma and polymyositis. We conducted a cross-sectional study to describe the clinical and immunological profile of patients with MCTD and compare four diagnostic criteria, ie, criteria Sharp, Kasukawa, Alarcón-Segovia, and Khan.

13 mm Diameter Tapped Titanium Tip

0-120-0010 13 mm
EUR 595

13 mm Diameter Solid Titanium Tip

0-120-0011 13 mm
EUR 533

19 mm Diameter Tapped Titanium Tip

0-120-0012 19 mm
EUR 639

19 mm Diameter Solid Titanium Tip

0-120-0013 19 mm
EUR 570

25 mm Diameter Tapped Titanium Tip

0-120-0014 25 mm
EUR 682

25 mm Diameter Solid Titanium Tip

0-120-0015 25 mm
EUR 614

Flat Replaceable Tips 13 mm Diameter Flat Titanium Tip

0-120-0016 13 mm
EUR 86
Description: use with corresponding Tapped Tips and Tapped Extender Tips

Flat Replaceable Tips 19 mm Diameter Flat Titanium Tip

0-120-0017 19 mm
EUR 92
Description: use with corresponding Tapped Tips and Tapped Extender Tips

Flat Replaceable Tips 25 mm Diameter Flat Titanium Tip

0-120-0018 25 mm
EUR 100
Description: use with corresponding Tapped Tips and Tapped Extender Tips

Titanium Cup Tip, 250 ml

0-120-0019 250 ml
EUR 1377
Description: includes Interface Washers

Microtube Tray, 8 Position (for 250 ml Cup Tip)

0-120-0021 each
EUR 113
Description: includes Interface Washers

Continuous Flow Chamber

0-120-0026 each
EUR 774
Description: includes Interface Washers

Interface Washers 1.5” Diameter, 5/Pkg

0-120-003 1.5'' Diameter
EUR 31

13 mm Diameter Solid Titanium Extender Tip

0-120-0032 13 mm
EUR 301

13 mm Diameter Tapped Titanium Extender Tip

0-120-0033 13 mm
EUR 362

19 mm Diameter Solid Titanium Extender Tip

0-120-0034 19 mm
EUR 315

19 mm Diameter Tapped Titanium Extender Tip

0-120-0035 19 mm
EUR 375

25 mm Diameter Solid Titanium Extender Tip

0-120-0036 25 mm
EUR 328

25 mm Diameter Tapped Titanium Extender Tip

0-120-0037 25 mm
EUR 389

KoldPod, 1.5ml Micro Tube

0-120-0038 1.5 ml
EUR 152
Description: Thermo conductive tube pods

KoldPod, 15ml Conical Tube

0-120-0039 15 ml
EUR 275
Description: Thermo conductive tube pods

KoldPod, 50ml Conical Tube

0-120-0040 50 ml
EUR 290
Description: Thermo conductive tube pods

Model 150 V/T Ultrasonic Homogenizer

0-121-0002 210-240V/50-60Hz
EUR 2920
Description: Delivers up to 150 Watts of ultrasonic power to the Titanium Tip. The Timer and Duty Cycle function increase preciosion in sample processing processing.

Model 300 V/T Ultrasonic Homogenizer

0-122-0002 210-240V/50-60Hz
EUR 3520
Description: Delivers up to 300 Watts of ultrasonic power to the Titanium Tip. The Timer and Duty Cycle function increase preciosion in sample.

SONABOZ Sound Abating Chamber

0-125-0001 each
EUR 1020
Description: Reduces cavitational sound emitted during processing.

Model 3000 Ultrasonic Homogenizer

0-127-0002 210-240V/50-60Hz
EUR 4120
Description: Delivers up to 300 Watts of ultrasonic power to the Titanium Tip and includes an intergrated Sound Abating Chmaber to reduce cavitational sound emitted during processing. The Timer and Duty Cycle function increase preciosion in sample.

Model 3000MP Ultrasonic Homogenizer

0-128-0002 210-240V/50-60Hz
EUR 4720
Description: Delivers up to 300 Watts of ultrasonic power to the Titanium Tip with preciosion control from a microprocessor and a graphical user interface displayed on a large (145 mm) LCD display. The integrated Sound Abating Chamber reduces cavitational sound emitted during processing.

OMNICON® Zone Reader, 210-240V/50-60Hz

0-131-0002 210-240V/50-60Hz
EUR 35200
Description: Designed to Perform multi-plate Assays on round 90/100mm Petri Dishes. The integrated LED illumination system provides transmitted light for brightfield and darkfield illumination of transparent media.

OMNI-Noculator Peni Cylinder Filler, 210-240V/50-60Hz

0-134-0002 210-240V/50-60Hz
EUR 32200
Description: A robotic liquid handling system designed to dispense Peni Cylinders and fill Peni Cylinders with the corresponding antibiotic liquid sample.

Peni Cylinder Dispenser with Manual Hopper

0-144-0002 each
EUR 5406
Description: Dispenser can be configured to dispense 4 or 6 Peni Cylinders onto a petri dish.

Peni Cylinder Dispenser with Motorized Hopper, 100-240V/50-60Hz

0-144-0003 100-240V/50-60Hz
EUR 6254
Description: The motorized hopper can be configured to dispense 4 or 6 Peni Cylinders onto a petri Dispenser can be disassembled for disinfection.

Stainless Steel Peni Cylinder with Flat Face

0-144-0005 6mm I.D. x 8mm O.D. x 10mm Long
EUR 399
Description: sold in packages of 100 pieces

Stainless Steel Peni Cylinder with Chamfered Face

0-144-0006 6mm I.D. x 8mm O.D. x 10mm Long
EUR 412
Description: sold in packages of 100 pieces

Custom development of ELISAs for other species or antibody isotypes not listed in the catalog. Custom testing of samples for IgG/IgM/IgA or total (IgG+IgM+IgA)

000-CUS Custom
EUR 602

Alpha-Bungarotoxin, CF®405S, 500 ug

00002 1UG
EUR 527
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-bungarotoxin, CF405s

00002 500uG
EUR 594
Description: Minimum order quantity: 1 unit of 500uG

Alpha-Bungarotoxin, CF®405S, 500 ug

00002-1 EA
EUR 527

Alpha-Bungarotoxin, CF®405S 100ug

00002-100ug 100uG
EUR 132
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®680R, 500 ug

9-00003
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®680R, 500 ug

00003-1 EA
EUR 527

Alpha-Bungarotoxin, CF®680R 100ug

9-00003
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®640R, 500 ug

9-00004
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®640R, 500 ug

00004-1 EA
EUR 527

Alpha-Bungarotoxin, CF®640R 100ug

9-00004
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®488A, 500 ug

9-00005
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®488A, 500 ug

00005-1 EA
EUR 527

Alpha-Bungarotoxin CF®488A 100ug

9-00005
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®568, 500 ug

9-00006
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®568, 500 ug

00006-1 EA
EUR 527

Alpha-Bungarotoxin, CF®568 100ug

9-00006
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®594, 500 ug

9-00007
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®594, 500 ug

00007-1 EA
EUR 527

Alpha-Bungarotoxin CF®594 100ug

9-00007
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®633, 500 ug

9-00009
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®633, 500 ug

00009-1 EA
EUR 527

Alpha-Bungarotoxin, CF®633 100ug

9-00009
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

SARS-CoV-2 Indicator Cell Line for RNA Replication - GFP Reporter only

0001-PP-001 1 cell line (can order x amount)
EUR 12000
Description: SARS-CoV-2 GFP reporter cell line using HEK293T (ACE2/TMPRSS2) cells

Alpha-Bungarotoxin, 1 mg

00010-1 1MG
EUR 193
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, 1 mg

00010-1-1 EA
EUR 193

Fluorescein-Alpha-Bungarotoxin, 500 ug

00011 500uG
EUR 376
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Fluorescein-Alpha-Bungarotoxin, 500 ug

00011-1 EA
EUR 376

Tetramethylrhodamine-Alpha-Bungarotoxin, 500 ug

00012 500uG
EUR 394
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Tetramethylrhodamine-Alpha-Bungarotoxin, 500 ug

00012-1 EA
EUR 394

Fluorescein-alpha-bungarotoxin, 10x50ug

00013 10ST
EUR 436
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Fluorescein-alpha-bungarotoxin, 10x50ug

00013-1 EA
EUR 436

Tetramethylrhodamine-A-Bungarotoxin, 10x50 ug

00014 10ST
EUR 494
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Tetramethylrhodamine-A-Bungarotoxin, 10x50 ug

00014-1 EA
EUR 494

Sulforhodamine 101-Alpha-Bungarotoxin, 500 ug

00015 500uG
EUR 494
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Sulforhodamine 101-Alpha-Bungarotoxin, 500 ug

00015-1 EA
EUR 494

Sulforhodamine 101-Alpha-Bungarotoxin, 50 ug

00016 10ST
EUR 560
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Sulforhodamine 101-Alpha-Bungarotoxin, 50 ug

00016-1 EA
EUR 560

Biotin-XX-A-Bungarotoxin, 500 ug

00017 500uG
EUR 455
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Biotin-XX-A-Bungarotoxin, 500 ug

00017-1 EA
EUR 455

Alpha-Bungarotoxin, CF®555, 500 ug

9-00018
  • Ask for price
  • Ask for price
  • 500uG
  • 100ug
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®555, 500 ug

00018-1 EA
EUR 527

Alpha-Bungarotoxin, CF®555 100ug

9-00018
  • Ask for price
  • Ask for price
  • 500uG
  • 100ug
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Acrylamide, Chemzymes Ultra Pure®

00019-100 100g
EUR 101.52
Description: 79-06-1

Acrylamide, Chemzymes Ultra Pure®

00019-500 500g
EUR 270
Description: 79-06-1

Biotin-cAMP, 1 mg

00020 1MG
EUR 298
Description: N/A

Biotin-cAMP, 1 mg

00020-1 20ST
EUR 298
Description: N/A

Biotin-cAMP, 50 ug

00020-1-1 EA
EUR 414

Biotin-cGMP, 1 mg

00021 1MG
EUR 331
Description: N/A

Biotin-cGMP, 1 mg

00021-1 20ST
EUR 331
Description: N/A

Biotin-cGMP, 20x50 ug

00021-1-1 EA
EUR 447

Cyanine 644-cAMP, 1 mg

00022 1MG
EUR 496
Description: N/A

Cyanine 644-cAMP, 1 mg

00022-1 20ST
EUR 496
Description: N/A

Cyanine 644-cAMP, 20x50 ug

00022-1-1 EA
EUR 647

Fluorescein Methotrexate, Triammonium Salt, 1 mg

00023 1MG
EUR 285
Description: N/A

Fluorescein Methotrexate, Triammonium Salt, 1 mg

00023-1 EA
EUR 285

Staurosporine

00025 100uG
EUR 100
Description: N/A

Staurosporine

00025-1 EA
EUR 100

Alpha-Bungarotoxin, CF®543, 500 ug

00026 500uG
EUR 527
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®543, 500 ug

00026-1 EA
EUR 527

Alpha-Bungarotoxin, CF®543, 100 ug

00026-100ug 1UG
EUR 132
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Rhodamine Phalloidin 300U

00027 300
EUR 364
Description: N/A

Rhodamine Phalloidin 300U

00027-1 EA
EUR 364

Biotin-XX-Phalloidin

00028 100U
EUR 466
Description: N/A

Biotin-XX-Phalloidin

00028-1 EA
EUR 466

Fluorescein-Phalloidin

00030 300U
EUR 364
Description: N/A

Fluorescein-Phalloidin

00030-1 EA
EUR 364

Rhodamine 110 Phalloidin

00032 300ST
EUR 364
Description: N/A

Rhodamine 110 Phalloidin

00032-1 EA
EUR 364

Sulforhodamine 101 (Texas Red®) Phalloidin

00033 300EU
EUR 364
Description: N/A

Sulforhodamine 101 (Texas Red®) Phalloidin

00033-1 EA
EUR 364

Phalloidin, CF®405M

00034 300U
EUR 482
Description: N/A

Phalloidin, CF®405M

00034-1 EA
EUR 482

Phalloidin, CF®405M

00034-T 50U
EUR 101
Description: N/A

Phalloidin, CF®405M

00034-T-1 EA
EUR 101

CF®488A-cAMP

00036 100ug
EUR 136
Description: N/A

CF®488A-cAMP

00036-1 EA
EUR 136

CF®640R-cAMP

00037 100ug
EUR 136
Description: N/A

CF®640R-cAMP

00037-1 EA
EUR 136

Phalloidin, CF555

00040 300U
EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF555

00040-T 50U
EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF®647, 300 U

00041 300U
EUR 482
Description: N/A

Phalloidin, CF®647, 300 U

00041-1 EA
EUR 482

Phalloidin, CF®647, 50 U

00041-T 50U
EUR 101
Description: N/A

Phalloidin, CF®647, 50 U

00041-T-1 EA
EUR 101

Phalloidin, CF®488A, 300 U

00042 300U
EUR 482
Description: N/A

Phalloidin, CF®488A, 300 U

00042-1 EA
EUR 482

Phalloidin, CF®488A, 50 U

00042-T 50U
EUR 101
Description: N/A

Phalloidin, CF®488A, 50 U

00042-T-1 EA
EUR 101

Phalloidin, CF®543, 300 U

00043 300U
EUR 482
Description: N/A

Phalloidin, CF®543, 300 U

00043-1 EA
EUR 482

Phalloidin, CF®543, 50 U

00043-T 50U
EUR 101
Description: N/A

Phalloidin, CF®543, 50 U

00043-T-1 EA
EUR 101

Phalloidin, CF®568, 300 U

00044 300U
EUR 482
Description: N/A

Phalloidin, CF®568, 300 U

00044-1 EA
EUR 482

Phalloidin, CF®568, 50 U

00044-T 50U
EUR 101
Description: N/A

Phalloidin, CF®568, 50 U

00044-T-1 EA
EUR 101

Phalloidin, CF®594, 300 U

00045 300U
EUR 482
Description: N/A

Phalloidin, CF®594, 300 U

00045-1 EA
EUR 482

Phalloidin, CF®594, 50 U

00045-T 50U
EUR 101
Description: N/A

Phalloidin, CF®594, 50 U

00045-T-1 EA
EUR 101

Phalloidin, CF®633, 300 U

00046 300U
EUR 482
Description: N/A

Phalloidin, CF®633, 300 U

00046-1 EA
EUR 482

Phalloidin, CF®633, 50 U

00046-T 50U
EUR 101
Description: N/A

Phalloidin, CF®633, 50 U

00046-T-1 EA
EUR 101

Phalloidin, CF®660R, 300 U

00047 300U
EUR 482
Description: N/A

Phalloidin, CF®660R, 300 U

00047-1 EA
EUR 482

Phalloidin, CF®660R, 50 U

00047-T 50U
EUR 101
Description: N/A

Phalloidin, CF®660R, 50 U

00047-T-1 EA
EUR 101

Phalloidin, CF®680R, 300 U

00048 300U
EUR 513
Description: N/A

Phalloidin, CF®680R, 300 U

00048-1 EA
EUR 513

Phalloidin, CF®680R, 50 U

00048-T 50U
EUR 101
Description: N/A

Phalloidin, CF®680R, 50 U

00048-T-1 EA
EUR 101

Phalloidin, CF®350, 300 U

00049 300U
EUR 482
Description: N/A

Phalloidin, CF®350, 300 U

00049-1 EA
EUR 482

Phalloidin, CF®350, 50 U

00049-T 50U
EUR 101
Description: N/A

Phalloidin, CF®350, 50 U

00049-T-1 EA
EUR 101

Phalloidin, CF®640R, 300 U

00050 300U
EUR 482
Description: N/A

Phalloidin, CF®640R, 300 U

00050-1 EA
EUR 482

Phalloidin, CF®640R, 50 U

00050-T 50U
EUR 101
Description: N/A

Phalloidin, CF®640R, 50 U

00050-T-1 EA
EUR 101

Phalloidin, CF®532, 300 U

00051 300U
EUR 482
Description: N/A

Phalloidin, CF®532, 300 U

00051-1 EA
EUR 482

Phalloidin, CF®532, 50 U

00051-T 50U
EUR 101
Description: N/A

Phalloidin, CF®532, 50 U

00051-T-1 EA
EUR 101

Phalloidin, CF®660C, 300 U

00052 300U
EUR 482
Description: N/A

Phalloidin, CF®660C, 300 U

00052-1 EA
EUR 482

Phalloidin, CF®660C, 50 U

00052-T 50U
EUR 101
Description: N/A

Phalloidin, CF®660C, 50 U

00052-T-1 EA
EUR 101

Phalloidin, CF®680, 300 U

00053 300U
EUR 513
Description: N/A

Phalloidin, CF®680, 300 U

00053-1 EA
EUR 513

Phalloidin, CF®680, 50 U

00053-T 50U
EUR 118
Description: N/A

Phalloidin, CF®680, 50 U

00053-T-1 EA
EUR 118

Phalloidin, CF®430, 300 U

00054 300U
EUR 491
Description: N/A

Phalloidin, CF®430, 300 U

00054-1 EA
EUR 491

Phalloidin, CF®430, 50 U

00054-T 50U
EUR 110
Description: N/A

Phalloidin, CF®430, 50 U

00054-T-1 EA
EUR 110

Phalloidin, CF®440, 300 U

00055 300U
EUR 491
Description: N/A

Phalloidin, CF®440, 300 U

00055-1 EA
EUR 491

Phalloidin, CF®440, 50 U

00055-T 50U
EUR 110
Description: N/A

Phalloidin, CF®440, 50 U

00055-T-1 EA
EUR 110

Phalloidin, CF®583R, 300 U

00064 1U
EUR 482
Description: N/A

Phalloidin, CF®583R, 300 U

00064-1 EA
EUR 482

Phalloidin, CF®583R, 50 U

00064-T 1U
EUR 108
Description: N/A

Phalloidin, CF®583R, 50 U

00064-T-1 EA
EUR 108

Cholera Toxin B, CF®405M Conjugate, 100 ug

00068 1UG
EUR 236
Description: N/A

A total of 291 patients treated from June 2007 to June 2017 and met the inclusion criteria were included in this study. The clinical diagnosis of MCTD is made on 111 patients, of whom 103 (92.8%) were women. Mean age at presentation was 39.3 years (SD ± 11.6). The most common organ system involved is the musculoskeletal system (95.5%), skin and mucosa (78.4%), and gastrointestinal and hepatobiliary system (56%).